Pilot Program

 

Current Grants
Name
Project Title
Fiegel, Jennifer, Ph.D. Development of LOS-Modified Nanoparticles for Improved Airway Epithelial Uptake
Grangrande, Paloma, Ph.D. RNA Aptamers for Cytoplasmic Delivery of Nucleic Acids
Liu, Xiaoming, Ph.D. High-Level Ectopic Expression of CFTR Imposes a Selective Disadvantage to Airway Epithelial Stem/Progenitor Cells
Maury, Wendy, Ph.D. Development of Highly Transducing Glycoproteins for Transgene Delivery Into Airway Epithelial Cells
Parekh, Kalpaj, M.D. Epithelial Stem Cells in a Lung Transplant Model
Raikwar, Sudhanshu, Ph.D.
Deviation of Insulin-Producing Cells from ES Cells

Past Grants
Name
Project Title
Banfi, Botond, Ph.D.
Thiocyanate Secretion-Dependent Oxidative Host Defense in CF and Health Airways
Bickenbach, Jackie, Ph.D.
Long Term Gene Expression by Epidermal Stem Cells
Cheng, Pi-Wan, Ph.D.
Ciliated Cell-Specific Gene Transfer
Cornell, Robert, Ph.D.
Generation of a Transgenic Zebrafish for Optimization of Gene Correction Methodologies
Davidson, Beverly, Ph.D.
Retroviral Gene Transfer to Airway Epithelia with MMLV-based Vectors
Dagle, John M., Ph.D.
Modified Antisense Oligonucleotides as Pseudomonas Antimicrobials
Duan, Dongsheng, Ph.D.
Analysis of rAAV Integration Specificity
Dunnwald, Martine, Ph.D.
Epidermal Stem Cells as a Gene Delivery System
Engelhardt, John F., Ph.D.
Circular Intermediates of rAAV as Novel Gene Transfer Vectors
Green, Steven H., Ph.D.
Gene Transfer into Spiral Ganglion Neurons in vivo
Harper, Scott, Ph.D.
Autoregulated AAV Vectors for Inducible RNA Interference
Henry, Michael, Ph.D.
Cellular Uptake and in vivo Pharmacodynamics of Cholesterol-siRNAs
Johnson, Alan, Ph.D.
Targeted Modulation of Vasopressin in Brain Magnocellular Neurons by Adenovirus-Mediated Gene Therapy
Jones, Bradley, Ph.D.
Gene Therapy for Phenylketonuria using an Adherent Bacterial Vector
Kang, Yubin, Ph.D.
Hematopoietic Stem Cell Gene Transfer for Hemophilia A
Keshavje, Shaf, M.D.
Repair of Damaged Lungs for Transplantation Using and Ex-vivo Gene Therapeutic Surgery
Klingelhutz, Aloysius J., Ph.D.
Reversibly Immortal Human Airway Epithelium
Kline, Joel, M.D.
Role of CPG Motifs in Plasmid DNA as a Barrier to Gene Transfer
Krieg, Arthur, M.D.
Development of Non-Immune Activating Gene Therapy Vectors for Cystic Fibrosis
Lamb, Fred, S., M.D., Ph.D.
Site-Directed Mutation of ES Cells by Oligonucleotides
Liang, Luchuan, Ph.D.
A Study of Epidermal Stem Cells in the Airway
Look, Dwight C., M.D.
Adenoviral Mechanisms for Inhibition of Interferon Signal Transduction
Lotery, Andrew, M.D.
Development of Gene Therapy for Batten Disease
McCaffrey, Anton, Ph.D.
Zinc Finger Nucleases Targeting Hepatitis B Virus DNAs
McCray, Paul, M.D.
Optimization of Retroviral Vectors for Mucosal Delivery
McLennan, Geoffrey, Ph.D.
Evaluating Gene Therapy Using a Fluorescent Marker
Mallampalli, Rama, M.D.
The CCT Promoter to Drive High-Level Expression of CFTR
Messerle, Louis, Ph.D.
AAV-Associated Cluster Contrast Agents for MR/CT Imaging of Vector Biodistribution
Ostedgaard, Lynda S., Ph.D.
Optimization of the CFTR Coding Sequence for Efficient Packaging into the AAV Vector
Rice, Kevin, Ph.D.
Reversibly PEGylated Gene Delivery Particles for Treating Cystic Fibrosis
Roller, Richard, Ph.D.
Cell-Specific Targeting of Herpes Simplex Virus in Gene Therapy for Cystic Fibrosis
Sanders, David A, Ph.D.
Direct Gene Transfer to Intact Airway Epithelia for CF
Singh, Pradeep, M.D.
CFTR-Mediatred Gene Correction of Biofilm Formation in the CF Airway
Sinn, Patrick, Ph.D.
Targeted Integration of a Lentiviral Vector
Stapleton, Jack, M.D.
A GBV-C Gene Therapy Vector for Cystic Fibrosis
Stecenko, Arlene, M.D.
Delivery of CFTR Protein Using membrane Translocating Sequences
Stein, Colleen S., Ph.D.
Transgene Tolerance: a Role for Apoptosis
Stipp, Christopher, Ph.D.
Enhancing the Neurite Outgrowth Potential of Neuronal Precursor Cells
Vermeer, Paola, Ph.D.
Goblet Cell Hyperplasia and Gene Transfer in CF
Weeks, Daniel, Ph.D.
Site Directed Mutagenesis Using Triplex Target Sites
Wiemer, DAvid, Ph.D. & Welsh, Michael, M.D., Co-PI
Modification of the Cell Surface to Aid Gene Transfer
Wu, Chun-Fang, Ph.D.
Harmful Effects of Integrating AAV Vectors
Yan, Ziying, Ph.D.
Hybrid rAAV Genomes for Gene Therapy of Cystic Fibrosis
Zabner, Joseph, M.D.
Study of Chimera Recombinant Adenovirus